PAR audit

Verdict

Status: revise connections
Confidence: high
Short verdict: Keep. PAR at DNA damage is well supported; broad connection to proteolytic condensates/destruction should be narrowed.

Node definition: PARP-mediated ADP-ribosylation/PAR chains, especially at DNA damage, recruiting repair factors and organizing local assemblies.
Incoming edges:
- SWITCH -> PAR: DDR kinases / → PARP context [context/dashed]
Outgoing edges:
- PAR -> DESTROY: PARylation → / proteolytic condensates

What is strongly supported: PARP1 rapidly detects DNA breaks and synthesizes PAR; PAR recruits repair, chromatin remodeling, and RNA-binding proteins and can nucleate transient repair assemblies.
What is context-dependent: Mono-ADP-ribosylation and poly-ADP-ribosylation have distinct writers/readers/erasers; PARP trapping/inhibitor effects complicate interpretation.
What is weak, controversial, or assay-biased: LLPS framing for PAR repair condensates is useful but can be overclaimed; direct material-property evidence matters.
What may be duplicate biology under another name: Overlaps with TETHER and ROUTER in DNA damage turnover/signaling.

Missing edges: Add PAR -> SHUFFLER/OPENER/WRITER chromatin repair context if scope allows; PARP recruits chromatin remodelers.
Excess edges: PAR -> DESTROY should be changed to PAR -> ROUTER/TETHER/repair-factor recruitment with a dashed degradation caveat.
Candidate splits: No split at current scale.
Candidate merges: No merge.
Candidate renames: ADP-RIBOSE.

Concrete graph change, if any: Keep; narrow degradation edge and mention chromatin remodeling/DNA repair recruitment.
Concrete technical-notes/blog wording change, if any: Mirror the graph recommendation in the glossary and relation catalogue, and explicitly mark the confidence/caveat where the claim is context-dependent or assay-sensitive.