MATURE audit

Verdict

Status: revise connections
Confidence: high
Short verdict: Keep, but separate cytosolic chaperone folding from ER UPR signaling in wording; both are proteostasis but different systems.

Node definition: Protein folding, refolding, triage, chaperone systems, and ER unfolded protein response.
Incoming edges:
- TEMPO -> MATURE: translation speed / → co-translational folding [context/dashed]
- FORGE -> MATURE: co-translational / folding
- ROUTER -> MATURE: Ub-chaperone / proteostasis [context/dashed]
Outgoing edges:
- MATURE -> BRAKE: UPR: PERK / = eIF2α kinase [context/dashed]
- MATURE -> DESTROY: misfolded cargo / triage [context/dashed]

What is strongly supported: Hsp70/Hsp90/CCT chaperones assist folding and triage; ER UPR sensors IRE1, PERK, and ATF6 tune translation, chaperones, ERAD, and apoptosis under ER stress.
What is context-dependent: Chaperones can stabilize clients, promote degradation via CHIP, or aid assembly; UPR outcomes vary by duration and stress intensity.
What is weak, controversial, or assay-biased: “Mature” can imply productive folding only; much of proteostasis is triage and degradation.
What may be duplicate biology under another name: Overlaps with DESTROY, BRAKE/PERK, INSPECTOR.

Missing edges: Add MATURE -> ROUTER via CHIP/ERAD ubiquitination; current MATURE -> DESTROY is okay but less mechanistic.
Excess edges: FORGE -> MATURE is correct but should say nascent-chain folding, not all mature protein folding.
Candidate splits: Optional split CHAPERONES and UPR.
Candidate merges: No merge.
Candidate renames: PROTEOSTASIS.

Concrete graph change, if any: Keep but rename/reword toward proteostasis and add CHIP/ERAD routing.
Concrete technical-notes/blog wording change, if any: Mirror the graph recommendation in the glossary and relation catalogue, and explicitly mark the confidence/caveat where the claim is context-dependent or assay-sensitive.