LICENSE audit

Verdict

Status: keep
Confidence: high
Short verdict: Keep. The node is correctly narrow: neddylation licenses CRL activity rather than directly degrading substrates.

Node definition: NEDD8 conjugation, mainly to cullins, activating cullin-RING ligases and thereby enabling ubiquitin-mediated substrate routing.
Incoming edges:
- None shown in current DOT.
Outgoing edges:
- LICENSE -> ROUTER: NEDD8 licenses CRLs / → Ub routing [emphasized]

What is strongly supported: Cullin neddylation changes CRL conformation and promotes ubiquitin transfer; deneddylation by COP9 signalosome resets CRLs; NAE inhibitors validate pathway importance.
What is context-dependent: NEDD8 can modify non-cullin substrates in some contexts, but cullins dominate canonical biology.
What is weak, controversial, or assay-biased: Treating neddylation as a general degradation route would be wrong; graph avoids this well.
What may be duplicate biology under another name: Overlaps with ROUTER.

Missing edges: Add LICENSE <-> SWITCH? CRL activation can be phosphorylation-regulated, but not necessary.
Excess edges: None major.
Candidate splits: No split.
Candidate merges: Could merge into ROUTER for a simpler map, but keeping it highlights CRL regulation.
Candidate renames: NEDD8-CRL.

Concrete graph change, if any: Keep as narrow upstream switch for ROUTER.
Concrete technical-notes/blog wording change, if any: Mirror the graph recommendation in the glossary and relation catalogue, and explicitly mark the confidence/caveat where the claim is context-dependent or assay-sensitive.