INSPECTOR audit

Verdict

Status: keep
Confidence: high
Short verdict: Keep. The node is well placed, but distinguish mRNA surveillance from nascent-chain degradation.

Node definition: Translation surveillance including ribosome rescue, no-go decay, nonstop decay, and ribosome-associated quality control of stalled nascent chains.
Incoming edges:
- FORGE -> INSPECTOR: elongation stalls / → RQC/NGD
- TEMPO -> INSPECTOR: codon/tRNA tempo / → ribosome stalls
Outgoing edges:
- INSPECTOR -> DESTROY: RQC ubiquitinates / nascent chains

What is strongly supported: Stalled ribosomes are recognized and split; RQC factors such as LTN1, NEMF, VCP/p97 and ribosome rescue factors promote nascent-chain ubiquitination and clearance; NGD/NSD target defective mRNAs.
What is context-dependent: Different stalls arise from damaged mRNA, polybasic tracts, rare codons, no stop codon, strong structures, or collided ribosomes.
What is weak, controversial, or assay-biased: Ribo-seq stall signatures can be confounded by inhibitors, library biases, and RNA structure; causal RQC needs perturbation evidence.
What may be duplicate biology under another name: Overlaps with TEMPO, TIMER, DESTROY, ROUTER.

Missing edges: Add INSPECTOR -> TIMER for NGD/NSD mRNA decay, not only INSPECTOR -> DESTROY.
Excess edges: FORGE -> INSPECTOR should be replaced by defective elongation/stalling inputs.
Candidate splits: No split for map scale, though RQC vs NGD/NSD are distinct.
Candidate merges: No merge.
Candidate renames: RQC-SURVEILLANCE.

Concrete graph change, if any: Keep; add mRNA decay output and revise initiation-stall edge.
Concrete technical-notes/blog wording change, if any: Mirror the graph recommendation in the glossary and relation catalogue, and explicitly mark the confidence/caveat where the claim is context-dependent or assay-sensitive.