What is strongly supported: mTORC1 phosphorylation of 4E-BPs promotes eIF4E availability and eIF4F assembly; eIF4A/eIF4G/PABP and 43S scanning control initiation efficiency.
What is context-dependent: mRNA-specific translation depends on 5UTR structure, uORFs, TOP motifs, RBPs, polyA, codon usage, and stress signaling.
What is weak, controversial, or assay-biased: Equating mTOR activity with global translation can overgeneralize; rapamycin/ATP-site inhibitors have substrate- and timing-specific effects.
What may be duplicate biology under another name: Overlaps with SHIELD, BRAKE, DECOY, BYPASS.
Missing or excessive graph structure
Missing edges: Add READERS -> FORGE bidirectional/activation and repression; add TIMER/codon optimality influence if detailed.
Excess edges: FORGE -> INSPECTOR “elongation stalls” is not directly from initiation; better TEMPO/defective mRNA -> INSPECTOR.
Candidate splits: No split.
Candidate merges: No merge.
Candidate renames: CAP-INITIATION.
Recommendation
Concrete graph change, if any: Keep; revise edge to INSPECTOR and broaden beyond mTOR only.
Concrete technical-notes/blog wording change, if any: Mirror the graph recommendation in the glossary and relation catalogue, and explicitly mark the confidence/caveat where the claim is context-dependent or assay-sensitive.
Key sources
PMID 25589112 — mTORC1 regulation of translation review.